{"type":"standard","title":"Murepavadin","displaytitle":"Murepavadin","namespace":{"id":0,"text":""},"wikibase_item":"Q27236621","titles":{"canonical":"Murepavadin","normalized":"Murepavadin","display":"Murepavadin"},"pageid":57413297,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Murepavadin_structure.svg/320px-Murepavadin_structure.svg.png","width":320,"height":481},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Murepavadin_structure.svg/512px-Murepavadin_structure.svg.png","width":512,"height":770},"lang":"en","dir":"ltr","revision":"1277583385","tid":"bedb17dc-f385-11ef-a7e3-204866bb369d","timestamp":"2025-02-25T14:35:23Z","description":"Chemical compound","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Murepavadin","revisions":"https://en.wikipedia.org/wiki/Murepavadin?action=history","edit":"https://en.wikipedia.org/wiki/Murepavadin?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Murepavadin"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Murepavadin","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Murepavadin","edit":"https://en.m.wikipedia.org/wiki/Murepavadin?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Murepavadin"}},"extract":" Murepavadin (POL7080) is a Pseudomonas specific peptidomimetic antibiotic. It is a synthetic cyclic beta hairpin peptidomimetic based on the cationic antimicrobial peptide protegrin I (PG-1) and the first example of an outer membrane protein-targeting antibiotic class with a novel, nonlytic mechanism of action, highly active and selective against the protein transporter LptD of Pseudomonas aeruginosa. In preclinical studies the compound was highly active on a broad panel of clinical isolates including multi-drug resistant Pseudomonas bacteria with outstanding in vivo efficacy in sepsis, lung, and thigh infection models. Intravenous murepavadin is in development for the treatment of bacterial hospital-acquired pneumonia and bacterial ventilator-associated pneumonia due to Pseudomonas aeruginosa.","extract_html":"
Murepavadin (POL7080) is a Pseudomonas specific peptidomimetic antibiotic. It is a synthetic cyclic beta hairpin peptidomimetic based on the cationic antimicrobial peptide protegrin I (PG-1) and the first example of an outer membrane protein-targeting antibiotic class with a novel, nonlytic mechanism of action, highly active and selective against the protein transporter LptD of Pseudomonas aeruginosa. In preclinical studies the compound was highly active on a broad panel of clinical isolates including multi-drug resistant Pseudomonas bacteria with outstanding in vivo efficacy in sepsis, lung, and thigh infection models. Intravenous murepavadin is in development for the treatment of bacterial hospital-acquired pneumonia and bacterial ventilator-associated pneumonia due to Pseudomonas aeruginosa.
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{"slip": { "id": 78, "advice": "Being kind is more rewarding than being right."}}
{"type":"standard","title":"Evides triangularis","displaytitle":"Evides triangularis","namespace":{"id":0,"text":""},"wikibase_item":"Q124715134","titles":{"canonical":"Evides_triangularis","normalized":"Evides triangularis","display":"Evides triangularis"},"pageid":77114268,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/c/c4/Evides_triangularis.jpg/330px-Evides_triangularis.jpg","width":320,"height":297},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/c/c4/Evides_triangularis.jpg","width":647,"height":600},"lang":"en","dir":"ltr","revision":"1265562755","tid":"87bcadb9-c45f-11ef-a57d-9f701e1f32bf","timestamp":"2024-12-27T14:33:25Z","description":"Species of beetles","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Evides_triangularis","revisions":"https://en.wikipedia.org/wiki/Evides_triangularis?action=history","edit":"https://en.wikipedia.org/wiki/Evides_triangularis?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Evides_triangularis"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Evides_triangularis","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Evides_triangularis","edit":"https://en.m.wikipedia.org/wiki/Evides_triangularis?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Evides_triangularis"}},"extract":"Evides triangularis is a South African wood-boring jewel beetle species in the family of Buprestidae. It has a metallic green coloration that is not reflective in the near-infrared renge of the spectrum.","extract_html":"
Evides triangularis is a South African wood-boring jewel beetle species in the family of Buprestidae. It has a metallic green coloration that is not reflective in the near-infrared renge of the spectrum.
"}